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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732227
Species: Homo sapiens
RGD Object: Gene
Symbol: NR3C1
Name: nuclear receptor subfamily 3 group C member 1
Acc ID: CHEBI:3207
Term: budesonide
Definition: A glucocorticoid steroid having a highly oxygenated pregna-1,4-diene structure. It is used mainly in the treatment of asthma and non-infectious rhinitis and for treatment and prevention of nasal polyposis.
Chemical ID: MESH:D019819
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR3C1affects bindingEXP 6480464CTDBudesonide binds to NR3C1 proteinPMID:19562681 PMID:8977508
NR3C1decreases expressionEXP 6480464CTDBudesonide results in decreased expression of NR3C1 mRNAPMID:9973176
NR3C1increases activityEXP 6480464CTDBudesonide results in increased activity of NR3C1 proteinPMID:10335001 PMID:15362971 PMID:21782008 PMID:9973176
NR3C1multiple interactionsEXP 6480464CTD2,2',3,5',6-pentachlorobiphenyl inhibits the reaction [Budesonide results in increased activity of NR3C1 protein]; 2,3',4,4',5-pentachlorobiphenyl inhibits the reaction [Budesonide results in increased activity of NR3C1 protein]; 2,4,2',4'-tetrachlorobiphenyl inhibits the reaction [Budesonide results in increased activity of NR3C1 protein]; 2,4,4'-trichlorobiphenyl inhibits the reaction [Budesonide results in increased activity of NR3C1 protein]; 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Budesonide results in increased activity of NR3C1 protein]; 2,4,5,2',5'-pentachlorobiphenyl inhibits the reaction [Budesonide results in increased activity of NR3C1 protein]; 2,5,2',5'-tetrachlorobiphenyl inhibits the reaction [Budesonide results in increased activity of NR3C1 protein]; Budesonide affects the reaction [Terbutaline results in increased expression of NR3C1 mRNA]PMID:21782008 PMID:9973176
NR3C1affects bindingISONr3c1 (Rattus norvegicus)6480464CTDBudesonide binds to NR3C1 proteinPMID:16507850 PMID:19562681
NR3C1multiple interactionsISONr3c1 (Rattus norvegicus)6480464CTD[Budesonide binds to NR3C1 protein] which results in increased expression of SLC51A mRNA; [Budesonide binds to NR3C1 protein] which results in increased expression of SLC51B mRNAPMID:19562681
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