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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:3090
Term: bicalutamide
Definition: A racemate comprising of equal amounts of (R)-bicalutamide and (S)-bicalutamide. It is an oral non-steroidal antiandrogen used in the treatment of prostate cancer and hirsutism.
Chemical ID: MESH:C053541
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDbicalutamide results in decreased expression of BAXPMID:11845989
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDbicalutamide results in increased expression of BAX proteinPMID:28500234
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Niclosamide co-treated with bicalutamide] results in increased expression of BAX protein; bicalutamide inhibits the reaction [Niclosamide results in decreased expression of BAX protein]PMID:27132804 PMID:28500234
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