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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69005
Species: Mus musculus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:3008
Term: bellidifolin
Definition: A member of the xanthone family that is bellidin substituted with a methyl group at O-3. A natural product found particularly in Swertia chirata and Gentianella campestris.
Chemical ID: MESH:C091291
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3decreases expressionISOSTAT3 (Homo sapiens)6480464CTDbellidifolin results in decreased expression of STAT3 mRNAPMID:33299414
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTDbellidifolin results in decreased expression of and results in decreased phosphorylation of STAT3 proteinPMID:33299414
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