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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736488
Species: Homo sapiens
RGD Object: Gene
Symbol: CCNE1
Name: cyclin E1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCNE1decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of CCNE1 mRNA; Benzo(a)pyrene results in decreased expression of CCNE1 proteinPMID:19027820
CCNE1decreases methylationEXP 6480464CTDBenzo(a)pyrene results in decreased methylation of CCNE1 exonPMID:27901495
CCNE1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of CCNE1 mRNA; Benzo(a)pyrene results in increased expression of CCNE1 proteinPMID:30236600 PMID:32234424 PMID:33411230
CCNE1increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of CCNE1 promoterPMID:27901495
CCNE1decreases expressionISOCcne1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CCNE1 mRNAPMID:19770486
CCNE1increases expressionISOCcne1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CCNE1 mRNAPMID:20713471
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