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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736022
Species: Mus musculus
RGD Object: Gene
Symbol: App
Name: amyloid beta precursor protein
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Appaffects expressionEXP 6480464CTDBenzo(a)pyrene affects the expression of APP proteinPMID:37364758
Appdecreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of APP mRNAPMID:19770486
Appmultiple interactionsEXP 6480464CTD[Benzo(a)pyrene affects the expression of APP protein] which results in increased abundance of amyloid beta-protein (1-42); Aspirin inhibits the reaction [[Benzo(a)pyrene affects the expression of APP protein] which results in increased abundance of amyloid beta-protein (1-42)]; Benzo(a)pyrene promotes the reaction [AHR protein binds to APP promoter]PMID:19654925 PMID:37364758
Appdecreases methylationISOAPP (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of APP 3' UTRPMID:27901495
Appincreases expressionISOAPP (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of APP mRNA; Benzo(a)pyrene results in increased expression of APP proteinPMID:22316170 PMID:25596431
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