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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2204
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cfb
Name: complement factor B
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cfbdecreases expressionISOCFB (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of CFB mRNAPMID:20106945 PMID:32234424
Cfbdecreases methylationISOCFB (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of CFB exonPMID:27901495
Cfbincreases expressionISOCfb (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CFB mRNAPMID:22228805
Cfbmultiple interactionsISOCfb (Mus musculus)6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CFB mRNAPMID:27858113
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