GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | SLC11A2 | decreases expression | EXP | | 6480464 | CTD | Copper results in decreased expression of SLC11A2 mRNA; Copper results in decreased expression of SLC11A2 protein | PMID:12220667 PMID:19685012 | SLC11A2 | increases expression | EXP | | 6480464 | CTD | Copper results in increased expression of SLC11A2 protein | PMID:26067577 | SLC11A2 | increases transport | EXP | | 6480464 | CTD | SLC11A2 protein results in increased transport of Copper | PMID:12220667 | SLC11A2 | multiple interactions | EXP | | 6480464 | CTD | [SLC11A2 protein co-treated with SLC31A1 protein] affects the uptake of Copper; Copper promotes the reaction [Estradiol results in increased expression of SLC11A2 mRNA]; Estradiol inhibits the reaction [Copper results in decreased expression of SLC11A2 protein]; Estradiol promotes the reaction [Copper affects the expression of SLC11A2 mRNA] | PMID:19685012 PMID:26067577 | SLC11A2 | increases expression | ISO | Slc11a2 (Rattus norvegicus) | 6480464 | CTD | Copper deficiency results in increased expression of SLC11A2 mRNA | PMID:17298691 PMID:19821111 | SLC11A2 | increases expression | ISO | Slc11a2 (Mus musculus) | 6480464 | CTD | Copper deficiency results in increased expression of SLC11A2 mRNA alternative form; Copper deficiency results in increased expression of SLC11A2 protein | PMID:23555700 | SLC11A2 | increases uptake | ISO | Slc11a2 (Mus musculus) | 6480464 | CTD | SLC11A2 mRNA alternative form results in increased uptake of Copper | PMID:24327293 | SLC11A2 | multiple interactions | ISO | Slc11a2 (Rattus norvegicus) | 6480464 | CTD | [[manganese chloride results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese] which affects the abundance of Copper; [[Manganese results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese] which affects the abundance of Copper; [Deferoxamine promotes the reaction [Doxorubicin results in increased expression of SLC11A2 protein]] which results in increased uptake of Copper | PMID:24089420 PMID:25575534 | SLC11A2 | multiple interactions | ISO | Slc11a2 (Mus musculus) | 6480464 | CTD | EPAS1 gene mutant form inhibits the reaction [Copper deficiency results in increased expression of SLC11A2 mRNA alternative form]; SLC11A2 protein affects the reaction [manganese chloride results in increased uptake of Copper] | PMID:22465424 PMID:23555700 | | ||||||||||||||||||||||
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