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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733440
Species: Homo sapiens
RGD Object: Gene
Symbol: BECN1
Name: beclin 1
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BECN1affects response to substanceEXP 6480464CTDBECN1 protein affects the susceptibility to RotenonePMID:18032788
BECN1increases expressionEXP 6480464CTDRotenone results in increased expression of BECN1 proteinPMID:18032788
BECN1multiple interactionsEXP 6480464CTD1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Rotenone results in increased expression of BECN1 protein]; BECN1 protein affects the reaction [resveratrol inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]]; SOD2 protein inhibits the reaction [Rotenone results in increased expression of BECN1 protein]PMID:18032788 PMID:21778691
BECN1affects response to substanceISOBecn1 (Mus musculus)6480464CTDBECN1 protein affects the susceptibility to RotenonePMID:26847702
BECN1decreases expressionISOBecn1 (Rattus norvegicus)6480464CTDRotenone results in decreased expression of BECN1 proteinPMID:27252111 PMID:35104487 PMID:35654124 PMID:36538285
BECN1decreases expressionISOBecn1 (Mus musculus)6480464CTDRotenone results in decreased expression of BECN1 mRNA; Rotenone results in decreased expression of BECN1 proteinPMID:21216964 PMID:23186747
BECN1increases expressionISOBecn1 (Rattus norvegicus)6480464CTDRotenone results in increased expression of BECN1 proteinPMID:25725130
BECN1multiple interactionsISOBecn1 (Rattus norvegicus)6480464CTD[Particulate Matter co-treated with Rotenone] results in decreased expression of BECN1 protein; Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BECN1 protein]]; empagliflozin inhibits the reaction [Rotenone results in decreased expression of BECN1 protein]; GAPDH mutant form promotes the reaction [Rotenone results in increased expression of BECN1 protein]; Quercetin inhibits the reaction [Rotenone results in decreased expression of BECN1 protein]; repaglinide inhibits the reaction [Rotenone results in decreased expression of BECN1 protein]; Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in decreased expression of BECN1 protein]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BECN1 protein]PMID:25725130 PMID:27252111 PMID:33823232 PMID:35104487 PMID:35654124 PMID:36538285
BECN1multiple interactionsISOBecn1 (Mus musculus)6480464CTD[CASP2 protein affects the susceptibility to Rotenone] which results in increased expression of BECN1 protein; [Particulate Matter co-treated with Rotenone] results in decreased expression of BECN1 protein; Acetylcysteine inhibits the reaction [[CASP2 protein affects the susceptibility to Rotenone] which results in increased expression of BECN1 protein]; Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in decreased expression of BECN1 protein]PMID:21216964 PMID:33823232
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