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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735652
Species: Homo sapiens
RGD Object: Gene
Symbol: AR
Name: androgen receptor
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ARdecreases expressionEXP 6480464CTDGenistein results in decreased expression of AR mRNAPMID:12391264 PMID:20706672
ARincreases activityEXP 6480464CTDGenistein results in increased activity of AR protein; Genistein results in increased activity of AR protein mutant formPMID:12391264 PMID:28728110
ARincreases expressionEXP 6480464CTDGenistein results in increased expression of AR proteinPMID:12391264
ARmultiple interactionsEXP 6480464CTDGenistein inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Genistein inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]; Genistein results in increased activity of and results in increased localization of AR proteinPMID:12391264 PMID:29162470 PMID:33049310
ARaffects bindingISOAr (Rattus norvegicus)6480464CTDGenistein binds to AR proteinPMID:14565775
ARdecreases expressionISOAr (Mus musculus)6480464CTDGenistein results in decreased expression of AR mRNAPMID:11880592 PMID:14871586
ARdecreases expressionISOAr (Rattus norvegicus)6480464CTDGenistein results in decreased expression of AR mRNAPMID:16443925 PMID:23410115 PMID:29863768
ARincreases expressionISOAr (Rattus norvegicus)6480464CTDGenistein results in increased expression of AR mRNAPMID:25031359
ARmultiple interactionsISOAr (Rattus norvegicus)6480464CTD[Diethylhexyl Phthalate co-treated with Genistein] results in increased expression of AR mRNA; [Genistein co-treated with vinclozolin] affects the expression of AR mRNA; [Genistein co-treated with vinclozolin] results in decreased expression of AR mRNA; Genistein inhibits the reaction [bisphenol A results in increased expression of AR protein]PMID:23410115 PMID:25031359 PMID:26260748 PMID:29863768
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