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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1342784
Species: Homo sapiens
RGD Object: Gene
Symbol: DDIT4L
Name: DNA damage inducible transcript 4 like
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DDIT4Lincreases expressionISODdit4l (Rattus norvegicus)6480464CTDCisplatin results in increased expression of DDIT4L mRNAPMID:22023808
DDIT4Lincreases expressionISODdit4l (Mus musculus)6480464CTDCisplatin results in increased expression of DDIT4L mRNAPMID:25270620
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