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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732911
Species: Mus musculus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1adecreases methylationISOCDKN1A (Homo sapiens)6480464CTDGlyphosate results in decreased methylation of CDKN1A promoterPMID:31751608
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDGlyphosate results in increased expression of CDKN1A mRNA; Glyphosate results in increased expression of CDKN1A proteinPMID:31295307 PMID:31751608 PMID:35485992
Cdkn1amultiple interactionsISOCdkn1a (Rattus norvegicus)6480464CTD[azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of CDKN1A mRNAPMID:33854195
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