GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfkb1 | increases response to substance | EXP | | 6480464 | CTD | NFKB1 gene mutant form results in increased susceptibility to Carbon Tetrachloride | PMID:15743782 | Nfkb1 | multiple interactions | EXP | | 6480464 | CTD | Carbon Tetrachloride affects the localization of and results in increased activity of NFKB1 protein; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of NFKB1 mRNA]; S-methylisothiopseudouronium analog inhibits the reaction [Carbon Tetrachloride affects the localization of and results in increased activity of NFKB1 protein] | PMID:16874658 PMID:18038451 | Nfkb1 | decreases expression | ISO | Nfkb1 (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride results in decreased expression of NFKB1 protein | PMID:8825185 | Nfkb1 | multiple interactions | ISO | Nfkb1 (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride results in increased activity of [NFKB1 protein binds to RELA protein]; Carbon Tetrachloride results in increased expression of [NFKB1 protein binds to RELA protein] | PMID:17429801 PMID:8825185 | | ||||||||||||||||||||||
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