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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551988
Species: Mus musculus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase family, member 1
Acc ID: CHEBI:21759
Term: N-methyl-N'-nitro-N-nitrosoguanidine
Definition: An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position
Chemical ID: MESH:D008769
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1affects cleavageEXP 6480464CTDMethylnitronitrosoguanidine affects the cleavage of PARP1 proteinPMID:20434464
Parp1increases activityEXP 6480464CTDMethylnitronitrosoguanidine results in increased activity of PARP1 proteinPMID:11593040
Parp1increases expressionEXP 6480464CTDMethylnitronitrosoguanidine results in increased expression of PARP1 proteinPMID:26954031
Parp1multiple interactionsEXP 6480464CTD[benzamide results in decreased activity of PARP1 protein] which results in decreased susceptibility to Methylnitronitrosoguanidine; [Methylnitronitrosoguanidine results in increased activity of PARP1 protein] which results in decreased abundance of NAD; benzamide inhibits the reaction [[Methylnitronitrosoguanidine results in increased activity of PARP1 protein] which results in decreased abundance of NAD]; Eugenol affects the reaction [Methylnitronitrosoguanidine affects the cleavage of PARP1 protein]; Hydrolyzable Tannins inhibits the reaction [[Methylnitronitrosoguanidine results in increased activity of PARP1 protein] which results in decreased abundance of NAD]; MUTYH protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of PARP1 protein]PMID:11593040 PMID:20434464 PMID:26954031
Parp1increases response to substanceISOPARP1 (Homo sapiens)6480464CTDPARP1 protein results in increased susceptibility to MethylnitronitrosoguanidinePMID:22001597
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