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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621282
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Birc3
Name: baculoviral IAP repeat-containing 3
Acc ID: CHEBI:18388
Term: apigenin
Definition: A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. It induces autophagy in leukaemia cells.
Chemical ID: MESH:D047310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Birc3increases cleavageISOBIRC3 (Homo sapiens)6480464CTDApigenin results in increased cleavage of BIRC3 proteinPMID:15486995
Birc3multiple interactionsISOBIRC3 (Homo sapiens)6480464CTD[TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BIRC3 proteinPMID:29247770
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