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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61890
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k5
Name: mitogen activated protein kinase kinase 5
Acc ID: CHEBI:180654
Term: N(4)-hydroxycytidine
Definition: A nucleoside analogue that is cytidine which carries a hydroxy group at the N(4)-positon. It has broad-spectrum antiviral activity against influenza, SARS-CoV , SARS-CoV-2 and MERS-CoV.
Chemical ID: MESH:C010737
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k5decreases expressionISOMap2k5 (Mus musculus)6480464CTDN(4)-hydroxycytidine results in decreased expression of MAP2K5 mRNAPMID:37748715
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