Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2482
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:692106480464CTDCalcitriol results in decreased expression of CYP7A1 mRNA

PMID:20371703
multiple interactionsISORGD:692106480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA], [Calcitriol binds to and results in increased activity of VDR protein] promotes the reaction [VDR protein binds to CYP7A1 promoter], [Calcitriol binds to and results in increased activity of VDR protein] which results in decreased expression of CYP7A1 mRNA, [Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA], [Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in decreased expression of CYP7A1 mRNA, Calcitriol inhibits the reaction [HNF4A protein binds to CYP7A1 mRNA], Calcitriol inhibits the reaction [HNF4A protein binds to CYP7A1 promoter], Calcitriol inhibits the reaction [NCOA2 protein binds to CYP7A1 mRNA], Calcitriol inhibits the reaction [NCOA2 protein binds to CYP7A1 promoter], Calcitriol inhibits the reaction [PPARGC1A protein binds to CYP7A1 mRNA], Calcitriol inhibits the reaction [PPARGC1A protein binds to CYP7A1 promoter], Calcitriol promotes the reaction [NCOR1 protein binds to CYP7A1 mRNA], Calcitriol promotes the reaction [NCOR1 protein binds to CYP7A1 promoter], Calcitriol promotes the reaction [NCOR2 protein binds to CYP7A1 mRNA], Calcitriol promotes the reaction [NCOR2 protein binds to CYP7A1 promoter], Calcitriol promotes the reaction [RXRA protein binds to CYP7A1 mRNA], Calcitriol promotes the reaction [VDR protein binds to CYP7A1 mRNA], CSK protein promotes the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA], NCOR1 protein promotes the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]], NCOR2 protein promotes the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]], Okadaic Acid promotes the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA], saracatinib inhibits the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA], U 0126 inhibits the reaction [Calcitriol inhibits the reaction [HNF4A protein binds to CYP7A1 mRNA]], U 0126 inhibits the reaction [Calcitriol inhibits the reaction [PPARGC1A protein binds to CYP7A1 mRNA]], U 0126 inhibits the reaction [Calcitriol promotes the reaction [NCOR1 protein binds to CYP7A1 mRNA]], U 0126 inhibits the reaction [Calcitriol promotes the reaction [NCOR2 protein binds to CYP7A1 mRNA]], U 0126 inhibits the reaction [Calcitriol promotes the reaction [RXRA protein binds to CYP7A1 mRNA]], U 0126 inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP7A1 mRNA]], U 0126 inhibits the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA]

PMID:19106115, PMID:20371703
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.