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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il18
Name: interleukin 18
Acc ID: CHEBI:17245
Term: carbon monoxide
Definition: A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.
Chemical ID: MESH:D002248
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il18decreases response to substanceISOIL18 (Homo sapiens)6480464CTDCarbon Monoxide results in decreased susceptibility to IL18 proteinPMID:18215737
Il18multiple interactionsISOIL18 (Homo sapiens)6480464CTDCarbon Monoxide inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Carbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein]PMID:18215737
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