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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733906
Species: Homo sapiens
RGD Object: Gene
Symbol: TIMP2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:16643
Term: L-methionine
Definition: The L-enantiomer of methionine.
Chemical ID: MESH:D008715
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TIMP2multiple interactionsISOTimp2 (Rattus norvegicus)6480464CTDMethionine inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA]PMID:15158331
TIMP2multiple interactionsISOTimp2 (Mus musculus)6480464CTD[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TIMP2 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TIMP2 mRNA; Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TIMP2 mRNA]PMID:18513333 PMID:20938992
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