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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732502
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:16480
Term: nitric oxide
Definition: A nitrogen oxide which is a free radical, each molecule of which consists of one nitrogen and one oxygen atom.
Chemical ID: MESH:D009569
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK1decreases expressionISOMapk1 (Rattus norvegicus)6480464CTDNitric Oxide results in decreased expression of MAPK1 proteinPMID:15640287
MAPK1decreases phosphorylationISOMapk1 (Rattus norvegicus)6480464CTDNitric Oxide results in decreased phosphorylation of MAPK1 proteinPMID:16575906
MAPK1multiple interactionsISOMapk1 (Rattus norvegicus)6480464CTDNitric Oxide affects the reaction [Ditiocarb results in increased phosphorylation of MAPK1 protein]; Nitric Oxide affects the reaction [NGF protein results in increased activity of MAPK1 protein]; Nitric Oxide inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]PMID:14713289 PMID:16389725 PMID:16603213
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