GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | XBP1 | increases expression | EXP | | 6480464 | CTD | Estradiol results in increased expression of XBP1 mRNA | PMID:14605097 PMID:20068169 PMID:25321415 PMID:25721606 PMID:31614463 PMID:32387340 | XBP1 | multiple interactions | EXP | | 6480464 | CTD | (+)-JQ1 compound inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to XBP1 promoter]]; (+)-JQ1 compound inhibits the reaction [Estradiol promotes the reaction [NCOA3 protein binds to XBP1 promoter]]; (+)-JQ1 compound inhibits the reaction [Estradiol results in increased expression of XBP1 mRNA]; Estradiol promotes the reaction [ESR1 protein binds to XBP1 enhancer]; Estradiol promotes the reaction [ESR1 protein binds to XBP1 promoter]; Estradiol promotes the reaction [NCOA3 protein binds to XBP1 promoter]; TBX21 protein inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to XBP1 enhancer]]; TBX21 protein inhibits the reaction [Estradiol results in increased expression of XBP1 mRNA] | PMID:20068169 PMID:25721606 | XBP1 | decreases expression | ISO | Xbp1 (Rattus norvegicus) | 6480464 | CTD | Estradiol results in decreased expression of XBP1 mRNA | PMID:32145629 | | ||||||||||||||||||||||
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