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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619561
Species: Homo sapiens
RGD Object: Gene
Symbol: VDR
Name: vitamin D receptor
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
VDRmultiple interactionsEXP 6480464CTDLipopolysaccharides inhibits the reaction [Calcitriol results in increased expression of VDR protein]; Lipopolysaccharides results in decreased expression of and results in decreased activity of VDR proteinPMID:15876428
VDRmultiple interactionsISOVdr (Rattus norvegicus)6480464CTD[Lipopolysaccharides co-treated with Glucose] results in decreased expression of VDR mRNA; [Lipopolysaccharides co-treated with Glucose] results in decreased expression of VDR protein; Calcitriol inhibits the reaction [[Lipopolysaccharides co-treated with Glucose] results in decreased expression of VDR mRNA]; Calcitriol inhibits the reaction [[Lipopolysaccharides co-treated with Glucose] results in decreased expression of VDR protein]PMID:21788014
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