GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | IL1B | increases abundance | EXP | | 6480464 | CTD | IL1B protein results in increased abundance of Hydrogen Peroxide | PMID:10802230 | IL1B | increases expression | EXP | | 6480464 | CTD | Hydrogen Peroxide results in increased expression of IL1B mRNA; Hydrogen Peroxide results in increased expression of IL1B protein | PMID:29274434 PMID:31306736 PMID:32949572 PMID:33955754 | IL1B | increases secretion | EXP | | 6480464 | CTD | Hydrogen Peroxide results in increased secretion of IL1B protein | PMID:29274434 | IL1B | multiple interactions | EXP | | 6480464 | CTD | (+)-JQ1 compound inhibits the reaction [[Hydrogen Peroxide co-treated with IL1B protein] promotes the reaction [BRD4 protein binds to CXCL8 promoter]]; (+)-JQ1 compound inhibits the reaction [[Hydrogen Peroxide co-treated with IL1B protein] promotes the reaction [BRD4 protein binds to IL6 promoter]]; (+)-JQ1 compound inhibits the reaction [[Hydrogen Peroxide co-treated with IL1B protein] promotes the reaction [RELA protein binds to CXCL8 promoter]]; (+)-JQ1 compound inhibits the reaction [[Hydrogen Peroxide co-treated with IL1B protein] promotes the reaction [RELA protein binds to IL6 promoter]]; (+)-JQ1 compound inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]]; (+)-JQ1 compound inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]]; (+)-JQ1 compound inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of IL6 mRNA]]; (+)-JQ1 compound inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of IL6 protein]]; 2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]]; 2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]]; 2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of IL6 mRNA]]; 2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of IL6 protein]]; [Hydrogen Peroxide co-treated with IL1B protein] promotes the reaction [BRD4 protein binds to CXCL8 promoter]; [Hydrogen Peroxide co-treated with IL1B protein] promotes the reaction [BRD4 protein binds to IL6 promoter]; [Hydrogen Peroxide co-treated with IL1B protein] promotes the reaction [RELA protein binds to CXCL8 promoter]; [Hydrogen Peroxide co-treated with IL1B protein] promotes the reaction [RELA protein binds to IL6 promoter]; AS602868 inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]]; AS602868 inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]]; AS602868 inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of IL6 mRNA]]; AS602868 inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of IL6 protein]]; BRD4 mutant form inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]]; BRD4 mutant form inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of IL6 protein]]; brusatol inhibits the reaction [Saponins inhibits the reaction [Hydrogen Peroxide results in increased expression of IL1B mRNA]]; Cannabidiol inhibits the reaction [Hydrogen Peroxide results in increased expression of IL1B mRNA]; Cannabidiol inhibits the reaction [Hydrogen Peroxide results in increased expression of IL1B protein]; Dexamethasone inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]]; diphenyliodonium inhibits the reaction [IL1B protein results in increased abundance of Hydrogen Peroxide]; Hydrogen Peroxide inhibits the reaction [Budesonide inhibits the reaction [IL1B protein results in increased acetylation of H4C16 protein]]; Hydrogen Peroxide promotes the reaction [IL1B protein affects the localization of and results in increased activity of RELA protein]; Hydrogen Peroxide promotes the reaction [IL1B protein promotes the reaction [BRD4 protein binds to CXCL8 promoter]]; Hydrogen Peroxide promotes the reaction [IL1B protein promotes the reaction [BRD4 protein binds to IL6 promoter]]; Hydrogen Peroxide promotes the reaction [IL1B protein promotes the reaction [RELA protein binds to CXCL8 promoter]]; Hydrogen Peroxide promotes the reaction [IL1B protein promotes the reaction [RELA protein binds to IL6 promoter]]; Hydrogen Peroxide promotes the reaction [IL1B protein results in increased acetylation of RELA protein]; Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]; Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of IL6 mRNA]; Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of IL6 protein]; Hydrogen Peroxide promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]; kahweol inhibits the reaction [Hydrogen Peroxide results in increased expression of IL1B protein]; oxophenylarsine inhibits the reaction [IL1B protein results in increased abundance of Hydrogen Peroxide]; Saponins inhibits the reaction [Hydrogen Peroxide results in increased expression of IL1B mRNA]; Saponins inhibits the reaction [Hydrogen Peroxide results in increased secretion of IL1B protein]; Selenium affects the reaction [IL1B protein results in increased abundance of Hydrogen Peroxide]; Selenium inhibits the reaction [IL1B protein results in increased abundance of Hydrogen Peroxide]; Theophylline inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Budesonide inhibits the reaction [IL1B protein results in increased acetylation of H4C16 protein]]]; Theophylline promotes the reaction [Dexamethasone inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]]] | PMID:10802230 PMID:15337792 PMID:18951874 PMID:24759736 PMID:29274434 PMID:31306736 PMID:33955754 | IL1B | increases expression | ISO | Il1b (Mus musculus) | 6480464 | CTD | Hydrogen Peroxide results in increased expression of IL1B protein | PMID:17640975 | IL1B | increases expression | ISO | Il1b (Rattus norvegicus) | 6480464 | CTD | Hydrogen Peroxide results in increased expression of IL1B protein | PMID:27430346 | IL1B | multiple interactions | ISO | Il1b (Mus musculus) | 6480464 | CTD | [IL1B protein co-treated with IFNG protein] results in increased abundance of Hydrogen Peroxide; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Hydrogen Peroxide] | PMID:19071154 | IL1B | multiple interactions | ISO | Il1b (Rattus norvegicus) | 6480464 | CTD | Cannabidiol inhibits the reaction [Hydrogen Peroxide results in increased expression of IL1B protein] | PMID:27430346 | | ||||||||||||||||||||||
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