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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730870
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP1A1
Name: cytochrome P450 family 1 subfamily A member 1
Acc ID: CHEBI:15948
Term: lycopene
Definition: An acyclic carotene commonly obtained from tomatoes and other red fruits.
Chemical ID: MESH:C015329
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP1A1decreases activityISOCyp1a1 (Mus musculus)6480464CTDlycopene results in decreased activity of CYP1A1 proteinPMID:19329757
CYP1A1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTDLycopene inhibits the reaction [Atrazine results in increased expression of CYP1A1 mRNA]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CYP1A1 mRNA]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CYP1A1 protein]PMID:26775023 PMID:36216167 PMID:36403809
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