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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62387
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdx1
Name: pancreatic and duodenal homeobox 1
Acc ID: CHEBI:15756
Term: hexadecanoic acid
Definition: A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Chemical ID: MESH:D019308
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdx1decreases expressionEXP 6480464CTDPalmitic Acid results in decreased expression of PDX1 proteinPMID:19513971 PMID:22819839
Pdx1multiple interactionsEXP 6480464CTD3-aminobenzamide inhibits the reaction [Palmitic Acid results in decreased expression of PDX1 protein]; geniposide inhibits the reaction [Palmitic Acid results in decreased expression of PDX1 protein]PMID:19513971 PMID:22819839
Pdx1decreases expressionISOPDX1 (Homo sapiens)6480464CTDPalmitic Acid results in decreased expression of PDX1 mRNAPMID:18155663
Pdx1multiple interactionsISOPDX1 (Homo sapiens)6480464CTDPalmitic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein]PMID:22558381
Pdx1multiple interactionsISOPdx1 (Mus musculus)6480464CTDPalmitic Acid inhibits the reaction [Glucose results in increased expression of PDX1 mRNA]PMID:22558381
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