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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352582
Species: Homo sapiens
RGD Object: Gene
Symbol: IL6
Name: interleukin 6
Acc ID: CHEBI:15727
Term: carnosine
Definition: A dipeptide that is the N-(beta-alanyl) derivative of L-histidine.
Chemical ID: MESH:D002336
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL6multiple interactionsEXP 6480464CTD[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased secretion of IL6 protein]; Carnosine inhibits the reaction [Glucose results in increased secretion of IL6 protein]PMID:30802477
IL6multiple interactionsISOIl6 (Mus musculus)6480464CTDasiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL6 protein]]; Carnosine inhibits the reaction [Acetaminophen results in increased expression of IL6 protein]; Carnosine inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL6 protein]]PMID:19799668 PMID:30802477
IL6multiple interactionsISOIl6 (Rattus norvegicus)6480464CTDCarnosine inhibits the reaction [Sodium Nitrite results in increased expression of IL6 protein]PMID:28266762
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