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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313525
Species: Homo sapiens
RGD Object: Gene
Symbol: MKI67
Name: marker of proliferation Ki-67
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MKI67decreases expressionEXP 6480464CTDTretinoin results in decreased expression of MKI67 mRNA; Tretinoin results in decreased expression of MKI67 proteinPMID:16249480 PMID:16461808 PMID:33167477
MKI67multiple interactionsISOMki67 (Rattus norvegicus)6480464CTDTretinoin inhibits the reaction [sodium arsenite results in decreased expression of MKI67 protein]PMID:21964460
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