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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh1a1
Name: aldehyde dehydrogenase 1 family, member A1
Acc ID: CHEBI:15343
Term: acetaldehyde
Definition: The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
Chemical ID: MESH:D000079
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh1a1increases oxidationEXP 6480464CTDALDH1A1 protein results in increased oxidation of AcetaldehydePMID:10998257
Aldh1a1increases metabolic processingISOAldh1a1 (Mus musculus)6480464CTDALDH1A1 protein results in increased metabolism of AcetaldehydePMID:21256123
Aldh1a1increases oxidationISOALDH1A1 (Homo sapiens)6480464CTDALDH1A1 protein results in increased oxidation of AcetaldehydePMID:18940187 PMID:23220590
Aldh1a1multiple interactionsISOAldh1a1 (Mus musculus)6480464CTD[CGA protein results in increased abundance of Acetaldehyde] which results in decreased expression of ALDH1A1 mRNA; [CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of ALDH1A1 mRNAPMID:22285649
Aldh1a1multiple interactionsISOALDH1A1 (Homo sapiens)6480464CTDCimetidine inhibits the reaction [ALDH1A1 protein results in increased oxidation of Acetaldehyde]PMID:23220590
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