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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628627
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2b3
Name: cytochrome P450, family 2, subfamily b, polypeptide 3
Acc ID: CHEBI:125675
Term: 5-methyltryptamine
Definition: A member of the class of tryptamines that is tryptamine substituted by a methyl group at position 5.
Chemical ID: MESH:C027552
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2b3decreases activityISOCYP2B6 (Homo sapiens)6480464CTD5-methyltryptamine analog results in decreased activity of CYP2B6 proteinPMID:26599973
Cyp2b3multiple interactionsISOCYP2B6 (Homo sapiens)6480464CTD[5-methyltryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of BupropionPMID:26599973
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