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GENE - TERM ANNOTATION REPORT

RGD ID: 9016780
Species: Chinchilla lanigera
RGD Object: Gene
Symbol: Kirrel2
Name: kirre like nephrin family adhesion molecule 2
Acc ID: DOID:1312
Term: focal segmental glomerulosclerosis
Definition: A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.
Definition Source(s): MESH:D005923
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kirrel2 ISOKIRREL2 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Focal segmental glomerulosclerosisPMID:19406966 PMID:25741868 PMID:26467025 PMID:28492532
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