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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737483
Species: Mus musculus
RGD Object: Gene
Symbol: Itgb3
Name: integrin beta 3
Acc ID: CHEBI:37941
Term: clopidogrel
Definition: A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group, the methylene hydrogen of which is replaced by a methoxycarbonyl group (the S enantiomer). A P2Y12 receptor antagonist, it is used to inhibit blood clots and prevent heart attacks.
Chemical ID: MESH:C055162
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Itgb3affects response to substanceISOITGB3 (Homo sapiens)6480464CTDITGB3 gene SNP affects the susceptibility to clopidogrelPMID:15166949
Itgb3decreases response to substanceISOITGB3 (Homo sapiens)6480464CTDITGB3 gene SNP results in decreased susceptibility to clopidogrelPMID:19530321
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