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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737316
Species: Homo sapiens
RGD Object: Gene
Symbol: CBS
Name: cystathionine beta-synthase
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CBSdecreases expressionISOCbs (Mus musculus)6480464CTDFolic Acid deficiency results in decreased expression of CBS proteinPMID:25384423
CBSdecreases expressionISOCbs (Rattus norvegicus)6480464CTDFolic Acid results in decreased expression of CBS mRNAPMID:21840474
CBSincreases activityISOCbs (Rattus norvegicus)6480464CTDFolic Acid results in increased activity of CBS proteinPMID:31721048
CBSincreases expressionISOCbs (Mus musculus)6480464CTDFolic Acid results in increased expression of CBS mRNAPMID:22959928
CBSmultiple interactionsISOCbs (Mus musculus)6480464CTD[Choline deficiency co-treated with Folic Acid deficiency co-treated with Methionine deficiency] results in decreased expression of CBS mRNA; [Choline deficiency co-treated with Folic Acid deficiency] affects the expression of CBS mRNA; Folic Acid inhibits the reaction [AGT protein results in decreased expression of CBS mRNA]; Folic Acid inhibits the reaction [AGT protein results in decreased expression of CBS protein]PMID:23439872 PMID:24386282 PMID:29127188
CBSmultiple interactionsISOCbs (Rattus norvegicus)6480464CTD[Fatty Acids, Omega-3 co-treated with Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of CBS mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of CBS mRNA; Folic Acid inhibits the reaction [phenylhydrazine results in decreased activity of CBS protein]; Homocysteine inhibits the reaction [Folic Acid results in increased activity of CBS protein]PMID:25003120 PMID:31721048 PMID:33788065
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