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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737111
Species: Homo sapiens
RGD Object: Gene
Symbol: EGR1
Name: early growth response 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EGR1affects expressionEXP 6480464CTDDoxorubicin affects the expression of EGR1 mRNAPMID:15205334
EGR1multiple interactionsEXP 6480464CTD[Doxorubicin co-treated with trichostatin A] results in increased expression of EGR1 mRNA; EGR1 protein affects the susceptibility to [Doxorubicin co-treated with trichostatin A]PMID:17330857
EGR1decreases expressionISOEgr1 (Mus musculus)6480464CTDDoxorubicin results in decreased expression of EGR1 proteinPMID:12714334
EGR1increases expressionISOEgr1 (Rattus norvegicus)6480464CTDDoxorubicin results in increased expression of EGR1 mRNAPMID:10625299
EGR1multiple interactionsISOEgr1 (Mus musculus)6480464CTD[Doxorubicin co-treated with Razoxane] results in decreased expression of EGR1 proteinPMID:12714334
EGR1multiple interactionsISOEgr1 (Rattus norvegicus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Doxorubicin results in increased expression of EGR1 mRNA]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of EGR1 mRNA]; Doxorubicin promotes the reaction [EGR1 protein binds to ATP2A2 promoter]; EGR1 gene affects the reaction [Doxorubicin results in decreased expression of ATP2A2 mRNA]PMID:10625299
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