Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	737091
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	HSD11B1
Name:	hydroxysteroid 11-beta dehydrogenase 1

Acc ID:	CHEBI:16827
Term:	corticosterone
Definition:	A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Chemical ID:	MESH:D003345

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
HSD11B1	decreases abundance	ISO	Hsd11b1 (Mus musculus)	6480464	CTD	HSD11B1 gene mutant form results in decreased abundance of Corticosterone	PMID:25061560
HSD11B1	increases chemical synthesis	ISO	Hsd11b1 (Mus musculus)	6480464	CTD	HSD11B1 protein results in increased chemical synthesis of Corticosterone	PMID:16751407
HSD11B1	increases chemical synthesis	ISO	Hsd11b1 (Rattus norvegicus)	6480464	CTD	HSD11B1 protein results in increased chemical synthesis of Corticosterone	PMID:23814014
HSD11B1	increases expression	ISO	Hsd11b1 (Rattus norvegicus)	6480464	CTD	Corticosterone results in increased expression of HSD11B1 mRNA	PMID:15755911
HSD11B1	increases oxidation	ISO	Hsd11b1 (Rattus norvegicus)	6480464	CTD	HSD11B1 protein results in increased oxidation of Corticosterone	PMID:26859423
HSD11B1	multiple interactions	ISO	Hsd11b1 (Mus musculus)	6480464	CTD	[[trimethyltin chloride results in increased abundance of trimethyltin] which co-treated with Corticosterone] results in increased expression of HSD11B1 mRNA; Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; Mifepristone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]]; Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]]	PMID:30993381
HSD11B1	multiple interactions	ISO	Hsd11b1 (Rattus norvegicus)	6480464	CTD	[HSD11B1 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone; [HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone; resveratrol inhibits the reaction [HSD11B1 protein results in increased chemical synthesis of Corticosterone]; Ziram inhibits the reaction [[HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone]	PMID:23814014 PMID:26859423

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