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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736867
Species: Mus musculus
RGD Object: Gene
Symbol: Abcc3
Name: ATP-binding cassette, sub-family C member 3
Acc ID: CHEBI:6030
Term: isoniazide
Definition: A carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine.
Chemical ID: MESH:D007538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc3decreases expressionISOAbcc3 (Rattus norvegicus)6480464CTDIsoniazid results in decreased expression of ABCC3 mRNAPMID:32673658
Abcc3multiple interactionsISOAbcc3 (Rattus norvegicus)6480464CTD[Lipopolysaccharides co-treated with Isoniazid] results in increased expression of ABCC3 mRNA; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of ABCC3 mRNA]PMID:25331106 PMID:32673658
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