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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:isoniazide
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Accession:CHEBI:6030 term browser browse the term
Definition:A carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine.
Synonyms:exact_synonym: pyridine-4-carbohydrazide
 related_synonym: 4-pyridinecarbohydrazide;   Formula=C6H7N3O;   InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10);   InChIKey=QRXWMOHMRWLFEY-UHFFFAOYSA-N;   Isoniazid;   Isonicotinsaeurehydrazid;   SMILES=NNC(=O)c1ccncc1;   isonicotinic acid hydrazide;   isonicotinic hydrazide;   isonicotinohydrazide;   isonicotinoylhydrazide;   pyridine-4-carboxylic acid hydrazide
 xref: Beilstein:119374;   CAS:54-85-3;   DrugBank:DB00951;   Drug_Central:1497;   Gmelin:82804;   KEGG:C07054;   KEGG:D00346;   LINCS:LSM-6682
 xref_mesh: MESH:D007538
 xref: MetaCyc:ISONIAZIDE;   PMID:15013786;   PMID:18220565;   PMID:19183459;   PMID:445303;   Reaxys:119374;   Wikipedia:Isoniazid


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isoniazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression ISO Isoniazid results in increased expression of A2M mRNA CTD PMID:12883083 NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186 		JBrowse link
G Abcb11 ATP-binding cassette, sub-family B member 11 multiple interactions
decreases expression		 ISO
EXP		 [Lipopolysaccharides co-treated with Isoniazid] results in decreased expression of ABCB11 mRNA; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of ABCB11 mRNA]
Isoniazid results in decreased expression of ABCB11 protein
[Rifampin co-treated with Isoniazid] results in decreased expression of ABCB11 protein
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of ABCB11 protein		 CTD PMID:25331106 PMID:25886055 PMID:32673658 PMID:35835356 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 increases expression ISO Isoniazid results in increased expression of ABCC1 mRNA CTD PMID:11752103 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 multiple interactions
decreases expression		 ISO [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of ABCC2 protein; [Lipopolysaccharides co-treated with Isoniazid] results in decreased expression of ABCC2 mRNA
Isoniazid results in decreased expression of ABCC2 mRNA		 CTD PMID:25331106 PMID:32673658 PMID:35835356 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 multiple interactions
decreases expression		 ISO [Lipopolysaccharides co-treated with Isoniazid] results in increased expression of ABCC3 mRNA; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of ABCC3 mRNA] CTD PMID:25331106 PMID:32673658 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823 		JBrowse link
G Abcc4 ATP-binding cassette, sub-family C member 4 decreases expression ISO Isoniazid results in decreased expression of ABCC4 mRNA CTD PMID:32673658 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631 		JBrowse link
G Abcc6 ATP-binding cassette, sub-family C member 6 decreases expression ISO Isoniazid results in decreased expression of ABCC6 mRNA CTD PMID:16260000 NCBI chr 7:45,625,804...45,679,915
Ensembl chr 7:45,616,979...45,679,726 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Isoniazid results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of ACSL4 protein CTD PMID:36878459 NCBI chr  X:141,100,989...141,173,792
Ensembl chr  X:141,100,989...141,173,531 		JBrowse link
G Afp alpha fetoprotein decreases expression ISO Isoniazid results in decreased expression of AFP mRNA CTD PMID:30008028 NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766 		JBrowse link
G Agpat3 1-acylglycerol-3-phosphate O-acyltransferase 3 multiple interactions
increases expression		 ISO [Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA]
Isoniazid results in increased expression of AGPAT3 mRNA		 CTD PMID:28619387 NCBI chr10:78,105,008...78,188,335
Ensembl chr10:78,105,012...78,188,323 		JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 increases expression ISO Isoniazid results in increased expression of AKR1B10 mRNA CTD PMID:28444390 NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885 		JBrowse link
G Alas1 aminolevulinic acid synthase 1 increases expression EXP
ISO		 Isoniazid results in increased expression of ALAS1 protein CTD PMID:27438535 PMID:30517741 NCBI chr 9:106,110,654...106,125,153
Ensembl chr 9:106,110,654...106,125,853 		JBrowse link
G Alb albumin affects binding ISO Isoniazid binds to ALB protein CTD PMID:25489718 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney increases activity
multiple interactions		 EXP Isoniazid results in increased activity of ALPL protein
[Rifampin co-treated with Isoniazid] results in increased activity of ALPL protein		 CTD PMID:25886055 NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695 		JBrowse link
G Apoa4 apolipoprotein A-IV affects response to substance EXP APOA4 affects the susceptibility to Isoniazid CTD PMID:24848797 NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757 		JBrowse link
G Apoa5 apolipoprotein A-V decreases expression
multiple interactions		 ISO Isoniazid results in decreased expression of APOA5 mRNA
[Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA]		 CTD PMID:28619387 NCBI chr 9:46,179,906...46,183,219
Ensembl chr 9:46,179,931...46,183,217 		JBrowse link
G App amyloid beta precursor protein increases expression ISO Isoniazid results in increased expression of APP mRNA CTD PMID:30008028 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Asl argininosuccinate lyase increases activity
multiple interactions		 ISO Isoniazid results in increased activity of ASL protein
[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein; silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein]		 CTD PMID:28619387 NCBI chr 5:130,040,099...130,053,222
Ensembl chr 5:130,040,099...130,058,088 		JBrowse link
G Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide increases expression ISO Isoniazid results in increased expression of ATP1B1 mRNA CTD PMID:30008028 NCBI chr 1:164,264,668...164,285,924
Ensembl chr 1:164,264,678...164,285,924 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta affects expression EXP Isoniazid affects the expression of ATP5F1B mRNA CTD PMID:24848797 NCBI chr10:127,919,176...127,926,257
Ensembl chr10:127,919,142...127,926,260 		JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 affects expression EXP Isoniazid affects the expression of ATP5MC1 mRNA CTD PMID:24848797 NCBI chr11:95,963,619...95,966,520
Ensembl chr11:95,959,678...95,966,496 		JBrowse link
G Atp5mc3 ATP synthase membrane subunit c locus 3 affects expression EXP Isoniazid affects the expression of ATP5MC3 mRNA CTD PMID:24848797 NCBI chr 2:73,738,791...73,742,793
Ensembl chr 2:73,738,791...73,741,670 		JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b affects expression EXP Isoniazid affects the expression of ATP5PB mRNA CTD PMID:24848797 NCBI chr 3:105,850,014...105,866,579
Ensembl chr 3:105,850,014...105,867,415 		JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 affects expression EXP Isoniazid affects the expression of ATP5PF mRNA CTD PMID:24848797 NCBI chr16:84,624,754...84,632,495
Ensembl chr16:84,624,754...84,632,513 		JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
affects expression		 EXP
ISO		 [Isoniazid co-treated with Rifampin] results in increased expression of BAX protein; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased expression of BAX protein]
Isoniazid results in increased expression of BAX protein
Quercetin inhibits the reaction [Isoniazid results in increased expression of BAX protein]
chrysin inhibits the reaction [Isoniazid results in increased expression of BAX protein]
Isoniazid results in increased expression of BAX mRNA
Isoniazid affects the expression of BAX protein		 CTD PMID:20433247 PMID:21419764 PMID:31332904 PMID:33121995 PMID:33771660 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bbox1 gamma-butyrobetaine hydroxylase 1 increases expression ISO Isoniazid results in increased expression of BBOX1 mRNA CTD PMID:30008028 NCBI chr 2:110,094,401...110,145,158
Ensembl chr 2:110,093,042...110,144,905 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression		 EXP
ISO		 [Isoniazid co-treated with Rifampin] results in decreased expression of BCL2 protein; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in decreased expression of BCL2 protein]
Isoniazid results in decreased expression of BCL2 protein
Quercetin inhibits the reaction [Isoniazid results in decreased expression of BCL2 protein]
Isoniazid results in decreased expression of BCL2 mRNA		 CTD PMID:20433247 PMID:21419764 PMID:31332904 PMID:33771660 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases expression
increases activity		 EXP
ISO		 [Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein; HGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein]; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein]
acadesine promotes the reaction [Isoniazid results in increased cleavage of CASP3 protein]; Quercetin inhibits the reaction [Isoniazid results in increased cleavage of CASP3 protein]
Isoniazid results in increased expression of CASP3 mRNA
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of CASP3
Isoniazid results in increased activity of CASP3 protein		 CTD PMID:20433247 PMID:21419764 PMID:23764483 PMID:28556920 PMID:31332904 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 increases cleavage
increases activity
multiple interactions		 ISO Isoniazid results in increased cleavage of CASP9 protein
Isoniazid results in increased activity of CASP9 protein
Quercetin inhibits the reaction [Isoniazid results in increased cleavage of CASP9 protein]		 CTD PMID:20433247 PMID:31332904 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Casr calcium-sensing receptor affects expression ISO Isoniazid affects the expression of CASR mRNA CTD PMID:20623750 NCBI chr16:36,310,947...36,382,605
Ensembl chr16:36,314,058...36,382,503 		JBrowse link
G Cat catalase decreases activity
multiple interactions		 ISO
EXP		 Isoniazid results in decreased activity of CAT protein
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of CAT protein; chrysin inhibits the reaction [Isoniazid results in decreased activity of CAT protein]		 CTD PMID:20433247 PMID:33121995 PMID:33771660 PMID:36878459 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression ISO Isoniazid results in decreased expression of CCR2 mRNA CTD PMID:20623750 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression EXP Isoniazid results in decreased expression of CEBPA mRNA; Isoniazid results in decreased expression of CEBPA protein CTD PMID:24128855 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression EXP Isoniazid results in decreased expression of CEBPB protein CTD PMID:24128855 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta decreases expression EXP Isoniazid results in decreased expression of CEBPD mRNA; Isoniazid results in decreased expression of CEBPD protein CTD PMID:24128855 NCBI chr16:15,705,150...15,707,409
Ensembl chr16:15,705,150...15,708,895 		JBrowse link
G Chpt1 choline phosphotransferase 1 affects response to substance EXP CHPT1 affects the susceptibility to Isoniazid CTD PMID:24848797 NCBI chr10:88,305,376...88,339,855
Ensembl chr10:88,288,607...88,339,935 		JBrowse link
G Cldn2 claudin 2 increases expression ISO Isoniazid results in increased expression of CLDN2 mRNA CTD PMID:30008028 NCBI chr  X:138,701,552...138,712,135
Ensembl chr  X:138,701,577...138,712,135 		JBrowse link
G Cox11 cytochrome c oxidase assembly protein 11, copper chaperone affects expression EXP Isoniazid affects the expression of COX11 mRNA CTD PMID:24848797 NCBI chr11:90,529,010...90,536,803
Ensembl chr11:90,528,999...90,535,757 		JBrowse link
G Cox17 cytochrome c oxidase assembly protein 17, copper chaperone affects expression EXP Isoniazid affects the expression of COX17 mRNA CTD PMID:24848797 NCBI chr16:38,167,332...38,173,125
Ensembl chr16:38,167,353...38,182,659 		JBrowse link
G Cox5b cytochrome c oxidase subunit 5B affects expression EXP Isoniazid affects the expression of COX5B mRNA CTD PMID:24848797 NCBI chr 1:36,730,568...36,732,469
Ensembl chr 1:36,730,530...36,732,762 		JBrowse link
G Cox6a1 cytochrome c oxidase subunit 6A1 affects expression EXP Isoniazid affects the expression of COX6A1 mRNA CTD PMID:24848797 NCBI chr 5:115,483,711...115,487,017
Ensembl chr 5:115,483,701...115,487,040 		JBrowse link
G Cox6b1 cytochrome c oxidase, subunit 6B1 affects expression EXP Isoniazid affects the expression of COX6B1 mRNA CTD PMID:24848797 NCBI chr 7:30,316,396...30,325,539
Ensembl chr 7:30,316,286...30,325,576 		JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 affects expression EXP Isoniazid affects the expression of COX7A2 mRNA CTD PMID:24848797 NCBI chr 9:79,662,523...79,667,135
Ensembl chr 9:79,662,643...79,667,160 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver affects expression EXP Isoniazid affects the expression of CPT1A mRNA CTD PMID:24848797 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases secretion ISO Isoniazid results in increased secretion of CXCL10 protein CTD PMID:28444390 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO [Isoniazid co-treated with lipopolysaccharide, E. coli O26-B6] results in decreased expression of CXCL8 mRNA CTD PMID:29594315 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cyb5a cytochrome b5 type A (microsomal) multiple interactions
decreases expression		 ISO [Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA; Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA]
Isoniazid results in decreased expression of CYB5A mRNA		 CTD PMID:28619387 NCBI chr18:84,869,463...84,897,996
Ensembl chr18:84,856,829...84,897,996 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression ISO Isoniazid results in increased expression of CYP27A1 mRNA CTD PMID:32673658 NCBI chr 1:74,752,311...74,777,056
Ensembl chr 1:74,752,733...74,777,051 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 decreases activity
multiple interactions		 ISO Isoniazid results in decreased activity of CYP2C8 protein
torsemide inhibits the reaction [Isoniazid results in decreased activity of CYP2C8 protein]		 CTD PMID:15304522 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects response to substance
increases metabolic processing
multiple interactions
increases expression
increases activity
increases response to substance		 ISO
EXP		 CYP2E1 gene polymorphism affects the susceptibility to Isoniazid; CYP2E1 gene SNP affects the susceptibility to Isoniazid
CYP2E1 protein results in increased metabolism of Isoniazid
2-(allylthio)pyrazine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 protein]; [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein; [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA; [Isoniazid results in increased activity of CYP2E1 protein] which results in increased metabolism of 4-dichlorobenzene; [Isoniazid results in increased expression of CYP2E1] which results in increased metabolism of Acetaminophen; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; diphenyleneiodonium inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]; Isoniazid inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]; Isoniazid results in increased expression of and results in increased activity of CYP2E1 protein; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; Rifampin inhibits the reaction [Isoniazid results in increased expression of CYP2E1 protein]; Thiram inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]; Tiopronin inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]
Isoniazid results in increased expression of CYP2E1; Isoniazid results in increased expression of CYP2E1 mRNA; Isoniazid results in increased expression of CYP2E1 protein
Berberine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 mRNA]
GSTM1 protein inhibits the reaction [CYP2E1 protein results in increased susceptibility to Isoniazid]		 CTD PMID:3113478 PMID:7710944 PMID:8074729 PMID:9051121 PMID:9065729 More... NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of CYP7A1 protein; [Lipopolysaccharides co-treated with Isoniazid] results in increased expression of CYP7A1 mRNA; obeticholic acid inhibits the reaction [Isoniazid results in increased expression of CYP7A1 mRNA]
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of CYP7A1 protein; [Isoniazid co-treated with Vitamin B 6] results in increased expression of CYP7A1 mRNA		 CTD PMID:25331106 PMID:32673658 PMID:35835356 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
decreases expression		 ISO Isoniazid results in increased expression of DDIT3 mRNA
Isoniazid results in decreased expression of DDIT3 mRNA		 CTD PMID:12883083 PMID:30008028 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Depp1 DEPP1 autophagy regulator increases expression ISO Isoniazid results in increased expression of DEPP1 mRNA CTD PMID:17175557 NCBI chr 6:116,627,645...116,629,808
Ensembl chr 6:116,627,570...116,629,755 		JBrowse link
G Epx eosinophil peroxidase increases oxidation
multiple interactions		 ISO EPX protein results in increased oxidation of Isoniazid
[EPX protein results in increased oxidation of Isoniazid] which results in increased chemical synthesis of isonicotinyl-NAD		 CTD PMID:30922765 NCBI chr11:87,754,824...87,766,362
Ensembl chr11:87,754,826...87,766,362 		JBrowse link
G Fech ferrochelatase decreases expression EXP
ISO		 Isoniazid results in decreased expression of FECH protein CTD PMID:27438535 PMID:30517741 NCBI chr18:64,589,613...64,622,169
Ensembl chr18:64,585,985...64,623,322 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked decreases activity ISO Isoniazid results in decreased activity of G6PD protein CTD PMID:20433247 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha decreases expression ISO Isoniazid results in decreased expression of GADD45A mRNA CTD PMID:20623750 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression ISO Isoniazid results in increased expression of GAPDH mRNA CTD PMID:12883083 NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
decreases expression
increases expression		 EXP
ISO		 Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GCLC mRNA]
Isoniazid results in decreased expression of GCLC mRNA
Isoniazid results in increased expression of GCLC mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of GCLC mRNA]		 CTD PMID:24128855 PMID:33121995 PMID:33771660 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit decreases expression
increases expression
multiple interactions		 ISO
EXP		 Isoniazid results in decreased expression of GCLM mRNA
Isoniazid results in increased expression of GCLM mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of GCLM mRNA]		 CTD PMID:30008028 PMID:33121995 PMID:33771660 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
increases expression		 ISO chrysin inhibits the reaction [Isoniazid results in increased expression of GFAP mRNA]; chrysin inhibits the reaction [Isoniazid results in increased expression of GFAP protein]
Isoniazid results in increased expression of GFAP mRNA; Isoniazid results in increased expression of GFAP protein		 CTD PMID:33121995 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions ISO [Lipopolysaccharides co-treated with Isoniazid] results in increased activity of GGT1 protein CTD PMID:25331106 NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1, soluble multiple interactions
increases activity		 EXP [Rifampin co-treated with Isoniazid] results in increased activity of GOT1 protein
Isoniazid results in increased activity of GOT1 protein		 CTD PMID:25886055 NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble increases activity
multiple interactions
increases expression		 ISO
EXP		 Isoniazid results in increased activity of GPT protein
[Rifampin co-treated with Isoniazid] results in increased activity of GPT protein
Quercetin inhibits the reaction [Isoniazid results in increased expression of GPT protein]
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPT protein; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of GPT protein; [Lipopolysaccharides co-treated with Isoniazid] results in increased activity of GPT protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of GPT protein]; Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]; Silybin inhibits the reaction [Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]]		 CTD PMID:25331106 PMID:25886055 PMID:28619387 PMID:31332904 PMID:35835356 More... NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPX4 mRNA; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPX4 protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPX4 protein] CTD PMID:36878459 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273 		JBrowse link
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) increases expression ISO Isoniazid results in increased expression of GSTA2 mRNA CTD PMID:12883083 NCBI chr 9:78,238,300...78,254,474
Ensembl chr 9:78,238,300...78,263,070 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 multiple interactions
decreases response to substance		 ISO GSTM1 protein inhibits the reaction [CYP2E1 protein results in increased susceptibility to Isoniazid]
GSTM1 protein results in decreased susceptibility to Isoniazid		 CTD PMID:28762043 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 decreases expression ISO Isoniazid results in decreased expression of GSTP1 mRNA CTD PMID:20623750 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Gstt1 glutathione S-transferase, theta 1 multiple interactions ISO GSTT1 gene polymorphism affects the susceptibility to [Isoniazid co-treated with Rifampin]; GSTT1 gene polymorphism results in increased susceptibility to [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide] CTD PMID:18397238 PMID:20485159 NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 affects expression ISO Isoniazid affects the expression of HAVCR1 mRNA CTD PMID:20623750 NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions EXP HGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased abundance of Reactive Oxygen Species]; HGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein] CTD PMID:23764483 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of HIF1A mRNA; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of HIF1A protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPX4 protein]; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of SLC7A11 protein]; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of GPT protein] CTD PMID:36878459 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
increases expression		 EXP
ISO		 Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]
Isoniazid results in decreased expression of HMOX1 mRNA
Isoniazid results in increased expression of HMOX1 mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of HMOX1 mRNA]		 CTD PMID:24128855 PMID:33121995 PMID:33771660 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hmox2 heme oxygenase 2 increases expression ISO Isoniazid results in increased expression of HMOX2 mRNA CTD PMID:12883083 NCBI chr16:4,544,225...4,584,606
Ensembl chr16:4,544,225...4,584,606 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases expression ISO Isoniazid results in increased expression of HPRT1 mRNA CTD PMID:12883083 NCBI chr  X:52,076,955...52,110,537
Ensembl chr  X:52,077,014...52,110,536 		JBrowse link
G Ifng interferon gamma increases secretion ISO Isoniazid results in increased secretion of IFNG protein CTD PMID:28444390 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il10 interleukin 10 increases secretion ISO Isoniazid results in increased secretion of IL10 protein CTD PMID:28444390 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il12a interleukin 12a increases secretion ISO Isoniazid results in increased secretion of IL12A protein CTD PMID:28444390 NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880 		JBrowse link
G Il12b interleukin 12b increases secretion ISO Isoniazid results in increased secretion of IL12B protein CTD PMID:28444390 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G Il17a interleukin 17A increases secretion ISO Isoniazid results in increased secretion of IL17A protein CTD PMID:28444390 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720 		JBrowse link
G Il1a interleukin 1 alpha increases secretion
increases expression		 ISO Isoniazid results in increased secretion of IL1A protein
Isoniazid results in increased expression of IL1A mRNA		 CTD PMID:28444390 PMID:32816093 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta increases secretion
increases expression
multiple interactions		 ISO Isoniazid results in increased secretion of IL1B protein
Isoniazid results in increased expression of IL1B mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of IL1B mRNA]		 CTD PMID:28444390 PMID:32816093 PMID:33121995 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Isoniazid co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il24 interleukin 24 increases expression ISO Isoniazid results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191 		JBrowse link
G Il6 interleukin 6 increases expression
increases secretion
multiple interactions		 EXP
ISO		 Isoniazid results in increased expression of IL6 protein
Isoniazid results in increased secretion of IL6 protein
Isoniazid results in increased expression of IL6 mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of IL6 mRNA]		 CTD PMID:19575532 PMID:28444390 PMID:33121995 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Inhbe inhibin beta-E increases expression ISO Isoniazid results in increased expression of INHBE mRNA CTD PMID:17175557 NCBI chr10:127,185,271...127,187,717
Ensembl chr10:127,184,726...127,190,280 		JBrowse link
G Izumo1r IZUMO1 receptor, JUNO decreases expression EXP Isoniazid results in decreased expression of IZUMO1R protein CTD PMID:33771660 NCBI chr 9:14,797,110...14,815,247
Ensembl chr 9:14,797,110...14,815,245 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 decreases expression EXP Isoniazid results in decreased expression of KEAP1 mRNA CTD PMID:33771660 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 affects response to substance EXP LAMP1 affects the susceptibility to Isoniazid CTD PMID:24848797 NCBI chr 8:13,209,161...13,225,338
Ensembl chr 8:13,209,161...13,225,338 		JBrowse link
G Lcn2 lipocalin 2 increases expression ISO Isoniazid results in increased expression of LCN2 mRNA CTD PMID:20623750 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264 		JBrowse link
G Map2 microtubule-associated protein 2 affects expression EXP Isoniazid affects the expression of MAP2 mRNA CTD PMID:22131109 NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Quercetin inhibits the reaction [Isoniazid results in decreased phosphorylation of MAPK1 protein]]; Quercetin inhibits the reaction [Isoniazid results in decreased phosphorylation of MAPK1 protein] CTD PMID:31332904 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Quercetin inhibits the reaction [Isoniazid results in decreased phosphorylation of MAPK3 protein]]; Quercetin inhibits the reaction [Isoniazid results in decreased phosphorylation of MAPK3 protein] CTD PMID:31332904 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression EXP Isoniazid results in increased expression of MGST1 mRNA CTD PMID:33771660 NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753 		JBrowse link
G Mir106b microRNA 106b decreases expression EXP Isoniazide decreased expression of miR106b miRNA in the liver RGD PMID:29554950 RGD:15042854 NCBI chr 5:138,163,999...138,164,080
Ensembl chr 5:138,163,999...138,164,080 		JBrowse link
G Mpo myeloperoxidase multiple interactions
increases oxidation		 ISO [[MPO protein results in increased oxidation of Isoniazid] which results in increased chemical synthesis of Free Radicals] which results in increased chemical synthesis of isonicotinyl-NAD; [MPO protein results in increased oxidation of Isoniazid] which results in increased chemical synthesis of Free Radicals; [MPO protein results in increased oxidation of Isoniazid] which results in increased chemical synthesis of isonicotinyl-NAD CTD PMID:26867495 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G mt-Co3 cytochrome c oxidase III, mitochondrial increases expression ISO Isoniazid results in increased expression of COX3 mRNA CTD PMID:12883083 NCBI chr MT:8,607...9,390
Ensembl chr MT:8,607...9,390 		JBrowse link
G Muc1 mucin 1, transmembrane increases expression ISO Isoniazid results in increased expression of MUC1 mRNA CTD PMID:30008028 NCBI chr 3:89,136,363...89,140,688
Ensembl chr 3:89,136,364...89,140,688 		JBrowse link
G Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) increases acetylation
affects acetylation
decreases expression
multiple interactions
decreases acetylation
increases metabolic processing
affects metabolic processing
affects response to substance		 ISO NAT2 protein polymorphism results in increased acetylation of Isoniazid; NAT2 protein results in increased acetylation of Isoniazid
NAT2 protein polymorphism affects the acetylation of Isoniazid
Isoniazid results in decreased expression of NAT2 mRNA
[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA]
[NAT2 gene polymorphism results in decreased acetylation of Isoniazid] which results in decreased abundance of acetylisoniazid; [NAT2 gene polymorphism results in decreased metabolism of Isoniazid] which results in increased abundance of hydrazine
NAT2 protein results in increased metabolism of Isoniazid
NAT2 protein affects the metabolism of Isoniazid; NAT2 protein polymorphism affects the metabolism of Isoniazid
NAT2 gene polymorphism affects the susceptibility to Isoniazid; NAT2 gene SNP affects the susceptibility to Isoniazid		 CTD PMID:11379777 PMID:11915035 PMID:15546075 PMID:15565348 PMID:15618686 More... NCBI chr 8:67,947,527...67,955,296
Ensembl chr 8:67,947,510...67,955,236 		JBrowse link
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 affects expression EXP Isoniazid affects the expression of NDUFA1 mRNA CTD PMID:24848797 NCBI chr  X:36,451,241...36,454,891
Ensembl chr  X:36,451,241...36,454,816 		JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 affects expression EXP Isoniazid affects the expression of NDUFA10 mRNA CTD PMID:24848797 NCBI chr 1:92,367,208...92,401,547
Ensembl chr 1:92,366,732...92,401,582 		JBrowse link
G Ndufa12 NADH:ubiquinone oxidoreductase subunit A12 affects expression EXP Isoniazid affects the expression of NDUFA12 mRNA CTD PMID:24848797 NCBI chr10:94,034,897...94,057,302
Ensembl chr10:94,034,582...94,057,305 		JBrowse link
G Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 affects expression EXP Isoniazid affects the expression of NDUFA13 mRNA CTD PMID:24848797 NCBI chr 8:70,346,813...70,355,208
Ensembl chr 8:70,346,830...70,355,208 		JBrowse link
G Ndufa4 Ndufa4, mitochondrial complex associated affects expression EXP Isoniazid affects the expression of NDUFA4 mRNA CTD PMID:24848797 NCBI chr 6:11,900,371...11,907,449
Ensembl chr 6:11,900,291...11,907,496 		JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 affects expression EXP Isoniazid affects the expression of NDUFA5 mRNA CTD PMID:24848797 NCBI chr 6:24,518,661...24,527,689
Ensembl chr 6:24,518,665...24,528,012 		JBrowse link
G Ndufa8 NADH:ubiquinone oxidoreductase subunit A8 affects expression EXP Isoniazid affects the expression of NDUFA8 mRNA CTD PMID:24848797 NCBI chr 2:35,926,336...35,939,350
Ensembl chr 2:35,926,338...35,939,418 		JBrowse link
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 affects expression EXP Isoniazid affects the expression of NDUFA9 mRNA CTD PMID:24848797 NCBI chr 6:126,798,826...126,826,107
Ensembl chr 6:126,798,684...126,826,099 		JBrowse link
G Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 affects expression EXP Isoniazid affects the expression of NDUFAB1 mRNA CTD PMID:24848797 NCBI chr 7:121,686,038...121,701,071
Ensembl chr 7:121,684,626...121,701,109 		JBrowse link
G Ndufb10 NADH:ubiquinone oxidoreductase subunit B10 affects expression EXP Isoniazid affects the expression of NDUFB10 mRNA CTD PMID:24848797 NCBI chr17:24,941,034...24,943,397
Ensembl chr17:24,941,034...24,943,452 		JBrowse link
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 affects expression EXP Isoniazid affects the expression of NDUFB2 mRNA CTD PMID:24848797 NCBI chr 6:39,569,499...39,576,777
Ensembl chr 6:39,569,508...39,580,316 		JBrowse link
G Ndufb3 NADH:ubiquinone oxidoreductase subunit B3 affects expression EXP Isoniazid affects the expression of NDUFB3 mRNA CTD PMID:24848797 NCBI chr 1:58,625,556...58,635,123
Ensembl chr 1:58,625,543...58,635,123 		JBrowse link
G Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 affects expression EXP Isoniazid affects the expression of NDUFB5 mRNA CTD PMID:24848797 NCBI chr 3:32,791,206...32,805,708
Ensembl chr 3:32,791,139...32,805,715 		JBrowse link
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 affects expression EXP Isoniazid affects the expression of NDUFB6 mRNA CTD PMID:24848797 NCBI chr 4:40,270,591...40,279,421
Ensembl chr 4:40,270,591...40,279,421 		JBrowse link
G Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 affects expression EXP Isoniazid affects the expression of NDUFB7 mRNA CTD PMID:24848797 NCBI chr 8:84,293,387...84,298,252
Ensembl chr 8:84,293,300...84,298,255 		JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 affects expression EXP Isoniazid affects the expression of NDUFS1 mRNA CTD PMID:24848797 NCBI chr 1:63,182,751...63,215,981
Ensembl chr 1:63,182,755...63,215,992 		JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 affects expression EXP Isoniazid affects the expression of NDUFS2 mRNA CTD PMID:24848797 NCBI chr 1:171,062,426...171,078,956
Ensembl chr 1:171,062,422...171,078,957 		JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 affects expression EXP Isoniazid affects the expression of NDUFS3 mRNA CTD PMID:24848797 NCBI chr 2:90,724,971...90,735,065
Ensembl chr 2:90,724,978...90,735,171 		JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase core subunit S4 affects expression EXP Isoniazid affects the expression of NDUFS4 mRNA CTD PMID:24848797 NCBI chr13:114,424,331...114,524,630
Ensembl chr13:114,424,331...114,524,794 		JBrowse link
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 affects expression EXP Isoniazid affects the expression of NDUFS8 mRNA CTD PMID:24848797 NCBI chr19:3,958,863...3,962,774
Ensembl chr19:3,958,863...3,962,774 		JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 affects expression EXP Isoniazid affects the expression of NDUFV1 mRNA CTD PMID:24848797 NCBI chr19:4,057,499...4,062,755
Ensembl chr19:4,057,384...4,062,806 		JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 affects expression EXP Isoniazid affects the expression of NDUFV2 mRNA CTD PMID:24848797 NCBI chr17:66,385,790...66,408,554
Ensembl chr17:66,385,633...66,408,554 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases activity
increases expression
multiple interactions		 EXP
ISO		 Isoniazid results in increased activity of NFE2L2 protein
Isoniazid results in increased expression of NFE2L2 mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of NFE2L2 mRNA]		 CTD PMID:30203046 PMID:33121995 PMID:33771660 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions
increases expression		 ISO chrysin inhibits the reaction [Isoniazid results in increased expression of NFKB1 mRNA] CTD PMID:33121995 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
decreases expression
increases expression		 EXP
ISO		 Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]
Isoniazid results in decreased expression of NQO1 mRNA
Isoniazid results in increased expression of NQO1 mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of NQO1 mRNA]		 CTD PMID:24128855 PMID:28444390 PMID:33121995 PMID:33771660 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions
decreases expression		 ISO obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of NR0B2 mRNA]
[Isoniazid co-treated with Vitamin B 6] results in decreased expression of NR0B2 mRNA		 CTD PMID:32673658 NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases expression		 ISO [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of NR1H4; [Lipopolysaccharides co-treated with Isoniazid] results in decreased expression of NR1H4 mRNA; [Lipopolysaccharides co-treated with Isoniazid] results in decreased expression of NR1H4 protein; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of NR1H4 mRNA]
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of NR1H4; [Isoniazid co-treated with Vitamin B 6] results in decreased expression of NR1H4 mRNA
isoniazide decreases expression of nr1h4 protein in rat liver		 CTD
RGD		 PMID:25331106 PMID:32673658 PMID:35835356 PMID:30068870 RGD:15042870 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity EXP Isoniazid results in increased activity of NR1I3 protein CTD PMID:30203046 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Nrf1 nuclear respiratory factor 1 decreases expression
multiple interactions		 ISO Isoniazid results in decreased expression of NRF1 protein
acadesine inhibits the reaction [Isoniazid results in decreased expression of NRF1 protein]		 CTD PMID:28556920 NCBI chr 6:30,047,984...30,153,462
Ensembl chr 6:30,047,987...30,153,457 		JBrowse link
G Nupr1 nuclear protein transcription regulator 1 increases expression ISO Isoniazid results in increased expression of NUPR1 mRNA CTD PMID:17175557 NCBI chr 7:126,222,418...126,224,642
Ensembl chr 7:126,222,421...126,230,033 		JBrowse link
G Ogdh oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) affects expression EXP Isoniazid affects the expression of OGDH mRNA CTD PMID:24848797 NCBI chr11:6,241,597...6,309,094
Ensembl chr11:6,241,633...6,306,642 		JBrowse link
G Park7 Parkinson disease (autosomal recessive, early onset) 7 affects expression EXP Isoniazid affects the expression of PARK7 mRNA CTD PMID:24848797 NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Isoniazid results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 1:84,014,014...84,317,550
Ensembl chr 1:84,014,017...84,341,901 		JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 increases expression ISO Isoniazid results in increased expression of PLOD2 mRNA CTD PMID:15997088 NCBI chr 9:92,421,828...92,490,481
Ensembl chr 9:92,424,276...92,490,481 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
decreases expression		 ISO [Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA]
Isoniazid results in decreased expression of POR mRNA		 CTD PMID:28619387 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity
multiple interactions		 EXP Isoniazid results in increased activity of PPARA protein
[Isoniazid co-treated with Rifampin] results in decreased expression of PPARA protein		 CTD PMID:30203046 PMID:36347327 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma decreases expression
multiple interactions		 ISO
EXP		 Isoniazid results in decreased expression of PPARG mRNA
[Isoniazid co-treated with Rifampin] results in decreased expression of PPARG protein
Isoniazid results in decreased expression of PPARG mRNA; Isoniazid results in decreased expression of PPARG protein		 CTD PMID:24128855 PMID:36347327 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions
decreases expression		 ISO acadesine inhibits the reaction [Isoniazid results in decreased expression of PPARGC1A protein] CTD PMID:28556920 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Psen1 presenilin 1 affects expression EXP Isoniazid affects the expression of PSEN1 mRNA CTD PMID:24848797 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Isoniazid results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) affects expression EXP Isoniazid affects the expression of SDHA mRNA CTD PMID:24848797 NCBI chr13:74,470,374...74,498,359
Ensembl chr13:74,470,373...74,498,399 		JBrowse link
G Sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) affects expression EXP Isoniazid affects the expression of SDHB mRNA CTD PMID:24848797 NCBI chr 4:140,688,582...140,706,509
Ensembl chr 4:140,688,514...140,706,504 		JBrowse link
G Sdhd succinate dehydrogenase complex, subunit D, integral membrane protein affects expression EXP Isoniazid affects the expression of SDHD mRNA CTD PMID:24848797 NCBI chr 9:50,507,640...50,515,149
Ensembl chr 9:50,507,657...50,515,112 		JBrowse link
G Sfn stratifin decreases expression ISO Isoniazid results in decreased expression of SFN mRNA CTD PMID:30008028 NCBI chr 4:133,327,867...133,329,163
Ensembl chr 4:133,327,867...133,329,479 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression		 ISO acadesine inhibits the reaction [Isoniazid results in decreased expression of SIRT1 protein]; Quercetin inhibits the reaction [Isoniazid results in decreased expression of SIRT1 protein] CTD PMID:28556920 PMID:31332904 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 multiple interactions
decreases expression		 ISO
EXP		 obeticholic acid promotes the reaction [Isoniazid results in decreased expression of SLC10A1 mRNA]
Isoniazid results in decreased expression of SLC10A1 protein
[Rifampin co-treated with Isoniazid] results in decreased expression of SLC10A1 protein
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of SLC10A1		 CTD PMID:25886055 PMID:32673658 PMID:35835356 NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479 		JBrowse link
G Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 affects expression ISO Isoniazid affects the expression of SLC11A1 mRNA CTD PMID:20623750 NCBI chr 1:74,414,318...74,429,974
Ensembl chr 1:74,414,354...74,425,221 		JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 multiple interactions ISO [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of SLC7A11 mRNA; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of SLC7A11 protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of SLC7A11 protein] CTD PMID:36878459 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063 		JBrowse link
G Slc7a5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 decreases expression ISO Isoniazid results in decreased expression of SLC7A5 mRNA CTD PMID:30008028 NCBI chr 8:122,607,885...122,634,425
Ensembl chr 8:122,607,889...122,634,433 		JBrowse link
G Slco1c1 solute carrier organic anion transporter family, member 1c1 decreases expression ISO Isoniazid results in decreased expression of SLCO1B1 mRNA CTD PMID:32673658 NCBI chr 6:141,470,080...141,515,903
Ensembl chr 6:141,470,094...141,515,903 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Isoniazid results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015 		JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression EXP Isoniazid results in increased expression of SOD1 mRNA CTD PMID:33771660 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions
affects expression		 ISO
EXP		 [SOD2 co-treated with CYP3A4] affects the susceptibility to Isoniazid
Isoniazid affects the expression of SOD2 mRNA		 CTD PMID:19501153 PMID:24848797 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Spp1 secreted phosphoprotein 1 affects expression
decreases expression		 ISO Isoniazid affects the expression of SPP1 mRNA
Isoniazid results in decreased expression of SPP1 mRNA		 CTD PMID:20623750 PMID:30008028 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916 		JBrowse link
G Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) increases expression ISO Isoniazid results in increased expression of SRXN1 mRNA CTD PMID:28444390 NCBI chr 2:151,946,738...151,953,296
Ensembl chr 2:151,947,436...151,953,296 		JBrowse link
G Surf1 surfeit gene 1 affects expression EXP Isoniazid affects the expression of SURF1 mRNA CTD PMID:24848797 NCBI chr 2:26,803,390...26,806,667
Ensembl chr 2:26,803,393...26,806,542 		JBrowse link
G Tnf tumor necrosis factor increases secretion
multiple interactions
increases expression		 ISO Isoniazid results in increased secretion of TNF protein
[Isoniazid co-treated with Zidovudine] results in increased expression of TNF protein; chrysin inhibits the reaction [Isoniazid results in increased expression of TNF protein]; Isoniazid promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased expression of TNF protein]		 CTD PMID:25331106 PMID:28444390 PMID:28619387 PMID:33121995 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tpo thyroid peroxidase decreases activity ISO Isoniazid results in decreased activity of TPO protein CTD PMID:26884060 NCBI chr12:30,104,658...30,182,983
Ensembl chr12:30,104,658...30,182,623 		JBrowse link
G Trak1 trafficking protein, kinesin binding 1 affects expression EXP Isoniazid affects the expression of TRAK1 mRNA CTD PMID:24848797 NCBI chr 9:121,126,568...121,303,985
Ensembl chr 9:121,126,568...121,303,984 		JBrowse link
G Trf transferrin increases expression ISO Isoniazid results in increased expression of TF mRNA CTD PMID:12883083 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643 		JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO Isoniazid results in increased expression of TRIB3 mRNA CTD PMID:30008028 NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952 		JBrowse link
G Txn2 thioredoxin 2 affects expression EXP Isoniazid affects the expression of TXN2 mRNA CTD PMID:24848797 NCBI chr15:77,799,251...77,813,194
Ensembl chr15:77,799,247...77,813,206 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Isoniazid results in increased expression of TXNRD1 mRNA CTD PMID:28444390 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546 		JBrowse link
G Txnrd2 thioredoxin reductase 2 affects expression EXP Isoniazid affects the expression of TXNRD2 mRNA CTD PMID:24848797 NCBI chr16:18,245,167...18,297,823
Ensembl chr16:18,245,134...18,297,823 		JBrowse link
G Uqcrb ubiquinol-cytochrome c reductase binding protein affects expression EXP Isoniazid affects the expression of UQCRB mRNA CTD PMID:24848797 NCBI chr13:67,048,640...67,053,414
Ensembl chr13:67,048,681...67,053,442 		JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 affects expression EXP Isoniazid affects the expression of UQCRC2 mRNA CTD PMID:24848797 NCBI chr 7:120,234,412...120,258,746
Ensembl chr 7:120,234,399...120,258,747 		JBrowse link
N'-acetylisoniazid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpo myeloperoxidase increases oxidation ISO MPO protein results in increased oxidation of (N)1-acetylisoniazid CTD PMID:26867495 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      application 21760
        pharmaceutical 21174
          drug 21174
            drug allergen 11916
              isoniazide 166
                N'-acetylisoniazid 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21920
                        carbon atom 21846
                          organic molecular entity 21846
                            heteroorganic entity 21500
                              organochalcogen compound 20983
                                organooxygen compound 20824
                                  carbon oxoacid 19606
                                    carboxylic acid 19602
                                      monocarboxylic acid 18969
                                        pyridinemonocarboxylic acid 418
                                          isonicotinic acid 172
                                            isoniazide 166
                                              N'-acetylisoniazid 1
paths to the root