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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736832
Species: Homo sapiens
RGD Object: Gene
Symbol: EGF
Name: epidermal growth factor
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EGFaffects activityEXP 6480464CTDfulvestrant affects the activity of EGF proteinPMID:19395996
EGFmultiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]; fulvestrant inhibits the reaction [EGF protein results in increased expression of PLAUR protein]; fulvestrant inhibits the reaction [EGF protein results in increased expression of TFF1 mRNA]PMID:19395996 PMID:19593637 PMID:20206645
EGFmultiple interactionsISOEgf (Rattus norvegicus)6480464CTDEGF protein inhibits the reaction [fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]]PMID:25813982
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