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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736793
Species: Homo sapiens
RGD Object: Gene
Symbol: GCLC
Name: glutamate-cysteine ligase catalytic subunit
Acc ID: CHEBI:8633
Term: puerarin
Definition: A hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 7 and 4' and a beta-D-glucopyranosyl residue at position 8 via a C-glycosidic linkage.
Chemical ID: MESH:C033607
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GCLCmultiple interactionsISOGclc (Mus musculus)6480464CTD[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA; [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC protein; NFE2L2 protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC protein]PMID:32763437
GCLCmultiple interactionsISOGclc (Rattus norvegicus)6480464CTD[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA; [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC proteinPMID:32763437
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