Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	736560
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	EPHX1
Name:	epoxide hydrolase 1

Acc ID:	CHEBI:27899
Term:	cisplatin
Definition:	A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID:	MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
EPHX1	increases expression	EXP		6480464	CTD	Cisplatin results in increased expression of EPHX1 mRNA	PMID:27392435
EPHX1	multiple interactions	EXP		6480464	CTD	[Cisplatin co-treated with jinfukang] results in increased expression of EPHX1 mRNA	PMID:27392435
EPHX1	affects expression	ISO	Ephx1 (Rattus norvegicus)	6480464	CTD	Cisplatin affects the expression of EPHX1 mRNA	PMID:18246545
EPHX1	increases expression	ISO	Ephx1 (Mus musculus)	6480464	CTD	Cisplatin results in increased expression of EPHX1 mRNA	PMID:21151649 PMID:21382384
EPHX1	increases expression	ISO	Ephx1 (Rattus norvegicus)	6480464	CTD	Cisplatin results in increased expression of EPHX1 mRNA	PMID:18246545

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