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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736447
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:48080
Term: brefeldin A
Definition: A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity.
Chemical ID: MESH:D020126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA5increases expressionEXP 6480464CTDBrefeldin A results in increased expression of HSPA5 mRNA; Brefeldin A results in increased expression of HSPA5 proteinPMID:12147617 PMID:18723477 PMID:19428936 PMID:20626587 PMID:27358234 PMID:32397857
HSPA5multiple interactionsEXP 6480464CTDBortezomib inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Brefeldin A inhibits the reaction [Shiga toxin subunit A results in increased cleavage of HSPA5 protein]PMID:18723477 PMID:33483759
HSPA5increases expressionISOHspa5 (Mus musculus)6480464CTDBrefeldin A results in increased expression of HSPA5 proteinPMID:20493918
HSPA5multiple interactionsISOHspa5 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Apigenin inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Glutathione inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]PMID:20493918
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