Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	736447
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	HSPA5
Name:	heat shock protein family A (Hsp70) member 5

Acc ID:	CHEBI:42758
Term:	aldehydo-D-glucose
Definition:	The open chain form of D-glucose.
Chemical ID:	MESH:D005947

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
HSPA5	increases expression	EXP		6480464	CTD	Glucose deficiency results in increased expression of HSPA5 mRNA; Glucose deficiency results in increased expression of HSPA5 protein; Glucose results in increased expression of HSPA5 mRNA; Glucose results in increased expression of HSPA5 protein	PMID:12147617 PMID:16380481 PMID:25451566 PMID:31022492
HSPA5	multiple interactions	EXP		6480464	CTD	4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 mRNA]; 4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]; [Glucose co-treated with TGFB1 protein] results in increased expression of HSPA5 protein; ATF6 protein modified form promotes the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]]; aucubin inhibits the reaction [[Glucose co-treated with TGFB1 protein] results in increased expression of HSPA5 protein]; glucogallin inhibits the reaction [Glucose results in increased expression of HSPA5 protein]; salubrinal inhibits the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]]; XBP1 mRNA alternative form promotes the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]]	PMID:25451566 PMID:31022492 PMID:35961541
HSPA5	decreases expression	ISO	Hspa5 (Mus musculus)	6480464	CTD	Glucose results in decreased expression of HSPA5 mRNA	PMID:17178593
HSPA5	decreases expression	ISO	Hspa5 (Rattus norvegicus)	6480464	CTD	Glucose results in decreased expression of HSPA5 mRNA	PMID:24349266
HSPA5	increases expression	ISO	Hspa5 (Mus musculus)	6480464	CTD	Glucose results in increased expression of HSPA5 mRNA; Glucose results in increased expression of HSPA5 protein	PMID:30076216
HSPA5	increases expression	ISO	Hspa5 (Rattus norvegicus)	6480464	CTD	Glucose deficiency results in increased expression of HSPA5 protein; Glucose results in increased expression of HSPA5 protein	PMID:21337367 PMID:34801538
HSPA5	multiple interactions	ISO	Hspa5 (Mus musculus)	6480464	CTD	2-aminoethoxydiphenyl borate inhibits the reaction [Glucose results in increased expression of HSPA5 protein]; Gadolinium inhibits the reaction [Glucose results in increased expression of HSPA5 protein]; Glucose affects the reaction [bisphenol A results in decreased expression of HSPA5 protein]; waixenicin A inhibits the reaction [Glucose results in increased expression of HSPA5 protein]	PMID:21705745 PMID:30076216
HSPA5	multiple interactions	ISO	Hspa5 (Rattus norvegicus)	6480464	CTD	Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of HSPA5 protein]; Metformin inhibits the reaction [Glucose results in increased expression of HSPA5 protein]	PMID:34801538

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