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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736066
Species: Homo sapiens
RGD Object: Gene
Symbol: SPP1
Name: secreted phosphoprotein 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SPP1affects expressionEXP 6480464CTDbisphenol A affects the expression of SPP1 mRNAPMID:20170705 PMID:30903817
SPP1decreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of SPP1 genePMID:31601247
SPP1increases expressionEXP 6480464CTDbisphenol A results in increased expression of SPP1 mRNAPMID:29718440
SPP1affects expressionISOSpp1 (Rattus norvegicus)6480464CTDbisphenol A affects the expression of SPP1 mRNAPMID:25181051
SPP1decreases expressionISOSpp1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of SPP1 mRNAPMID:32156529 PMID:37105096 PMID:37611474
SPP1decreases expressionISOSpp1 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of SPP1 mRNAPMID:22504913 PMID:27257137 PMID:30816183 PMID:34947998
SPP1increases expressionISOSpp1 (Mus musculus)6480464CTDbisphenol A results in increased expression of SPP1 mRNAPMID:30951980
SPP1increases expressionISOSpp1 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of SPP1 mRNAPMID:31697385
SPP1multiple interactionsISOSpp1 (Mus musculus)6480464CTD[bisphenol A co-treated with Tretinoin] results in decreased expression of SPP1 mRNAPMID:30951980
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