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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735908
Species: Mus musculus
RGD Object: Gene
Symbol: Chrna2
Name: cholinergic receptor nicotinic alpha 2 subunit
Acc ID: CHEBI:15355
Term: acetylcholine
Definition: Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter.
Chemical ID: MESH:D000109
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna2multiple interactionsISOChrna2 (Rattus norvegicus)2303194RGDacetylcholine affects binding competes with [Epibatidine binds to Chrna2 protein] 
Chrna2affects response to substanceISOCHRNA2 (Homo sapiens)6480464CTDCHRNA2 gene mutant form affects the susceptibility to AcetylcholinePMID:19383498
Chrna2multiple interactionsISOChrna2 (Rattus norvegicus)6480464CTDAcetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]; Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]PMID:7808438
Chrna2multiple interactionsISOCHRNA2 (Homo sapiens)6480464CTD1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 1-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 2-butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]; Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; crotonyl alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; isobutyl alcohol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; n-pentanol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; tert-Butyl Alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]PMID:11821649 PMID:9454827
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