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GENE - TERM ANNOTATION REPORT

RGD ID: 735648
Species: Homo sapiens
RGD Object: Gene
Symbol: NRAS
Name: NRAS proto-oncogene, GTPase
Acc ID: DOID:9119
Term: acute myeloid leukemia
Definition: A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. (DO)
Definition Source(s): http://cancergenome.nih.gov/cancersselected/acutemyeloidleukemia "DO" "DO", http://en.wikipedia.org/wiki/Acute_myeloid_leukemia "DO" "DO", http://www.cancer.gov/dictionary?cdrid=44363 "DO" "DO", https://www.cancer.org/cancer/acute-myeloid-leukemia/detection-diagnosis-staging/how-classified.html "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NRAS IAGP 11060151RGD  
NRASdisease_progressionIAGP 11535045RGDDNA:missense mutation:cds: 
NRASdisease_progressionISONras (Mus musculus)11070616RGD  
NRAS EXP 11554173CTDCTD Direct Evidence: marker/mechanismPMID:27992414
NRAS IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemiaPMID:18633438 PMID:25741868 PMID:3102434
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