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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735648
Species: Homo sapiens
RGD Object: Gene
Symbol: NRAS
Name: NRAS proto-oncogene, GTPase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NRASaffects expressionISONras (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of NRAS mRNAPMID:21570461
NRASdecreases expressionISONras (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of NRAS mRNAPMID:33387578
NRASmultiple interactionsISONras (Mus musculus)6480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of NRAS mRNAPMID:25975270
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