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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735621
Species: Homo sapiens
RGD Object: Gene
Symbol: CXCL2
Name: C-X-C motif chemokine ligand 2
Acc ID: CHEBI:5615
Term: halothane
Definition: A haloalkane comprising ethane having three flouro substituents at the 1-position as well as bromo- and chloro substituents at the 2-position.
Chemical ID: MESH:D006221
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CXCL2decreases expressionISOCxcl2 (Rattus norvegicus)6480464CTDHalothane results in decreased expression of CXCL2 mRNAPMID:15564938
CXCL2increases expressionISOCxcl2 (Rattus norvegicus)6480464CTDHalothane results in increased expression of CXCL2 mRNAPMID:10422944
CXCL2increases expressionISOCxcl2 (Mus musculus)6480464CTDHalothane results in increased expression of CXCL2 mRNA; Halothane results in increased expression of CXCL2 proteinPMID:19633216 PMID:21501669 PMID:22157104 PMID:24598351 PMID:24747151 PMID:32795494
CXCL2multiple interactionsISOCxcl2 (Mus musculus)6480464CTD[Progesterone co-treated with Halothane] results in increased expression of CXCL2 mRNA; [Progesterone co-treated with Halothane] results in increased expression of CXCL2 protein; Dantrolene inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]; Estradiol inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]]; gadolinium chloride inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of CXCL2 mRNA]; Mifepristone inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL2 mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of CXCL2 mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of CXCL2 mRNA]; U 0126 inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of CXCL2 mRNA]PMID:21501669 PMID:22157104 PMID:32795494
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