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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735621
Species: Homo sapiens
RGD Object: Gene
Symbol: CXCL2
Name: C-X-C motif chemokine ligand 2
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CXCL2decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of CXCL2 mRNAPMID:38568856
CXCL2decreases expressionISOCxcl2 (Mus musculus)6480464CTDCadmium Chloride results in decreased expression of CXCL2 mRNAPMID:28666365
CXCL2increases expressionISOCxcl2 (Rattus norvegicus)6480464CTDCadmium Chloride results in increased expression of CXCL2 mRNAPMID:19010381
CXCL2increases expressionISOCxcl2 (Mus musculus)6480464CTDCadmium Chloride results in increased expression of CXCL2 mRNA; Cadmium Chloride results in increased expression of CXCL2 proteinPMID:16413704 PMID:24449419 PMID:30375035 PMID:7536360 PMID:9707512
CXCL2increases methylationISOCxcl2 (Rattus norvegicus)6480464CTDCadmium Chloride results in increased methylation of CXCL2 promoterPMID:22457795
CXCL2multiple interactionsISOCxcl2 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of CXCL2 mRNA]; lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [Cadmium Chloride results in increased expression of CXCL2 mRNA]PMID:24449419 PMID:7536360
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