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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735621
Species: Homo sapiens
RGD Object: Gene
Symbol: CXCL2
Name: C-X-C motif chemokine ligand 2
Acc ID: CHEBI:3139
Term: bleomycin A2
Definition: A bleomycin that has formula C55H84N17O21S3.
Chemical ID: MESH:D001761
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CXCL2increases expressionEXP 6480464CTDBleomycin results in increased expression of CXCL2 proteinPMID:18684396
CXCL2increases expressionISOCxcl2 (Mus musculus)6480464CTDBleomycin results in increased expression of CXCL2 mRNAPMID:22687607 PMID:26520185
CXCL2increases secretionISOCxcl2 (Mus musculus)6480464CTDBleomycin results in increased secretion of CXCL2 proteinPMID:22687607 PMID:26600069
CXCL2multiple interactionsISOCxcl2 (Rattus norvegicus)6480464CTD[Bleomycin co-treated with Tobacco Smoke Pollution] results in increased expression of CXCL2 proteinPMID:33516805
CXCL2multiple interactionsISOCxcl2 (Mus musculus)6480464CTD3-aminobenzamide inhibits the reaction [Bleomycin results in increased secretion of CXCL2 protein]; Calcitriol inhibits the reaction [Bleomycin results in increased expression of CXCL2 mRNA]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Bleomycin results in increased secretion of CXCL2 protein]; TRPM2 gene mutant form inhibits the reaction [Bleomycin results in increased secretion of CXCL2 protein]PMID:26520185 PMID:26600069
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