GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CXCL2 | increases expression | EXP | | 6480464 | CTD | Lipopolysaccharides results in increased expression of CXCL2 mRNA; Lipopolysaccharides results in increased expression of CXCL2 protein | PMID:10718115 PMID:18684396 PMID:35811015 | CXCL2 | multiple interactions | EXP | | 6480464 | CTD | [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of CXCL2 mRNA; [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of CXCL2 mRNA; ANXA1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA] | PMID:21777521 PMID:35811015 | CXCL2 | increases expression | ISO | Cxcl2 (Rattus norvegicus) | 6480464 | CTD | Lipopolysaccharides results in increased expression of CXCL2 mRNA; Lipopolysaccharides results in increased expression of CXCL2 protein | PMID:16401727 PMID:16415329 PMID:21362633 PMID:23568217 PMID:24333275 PMID:33727093 | CXCL2 | increases expression | ISO | Cxcl2 (Mus musculus) | 6480464 | CTD | Lipopolysaccharides results in increased expression of CXCL2 mRNA; Lipopolysaccharides results in increased expression of CXCL2 protein | PMID:10027076 PMID:10975854 PMID:11605937 PMID:11818323 PMID:12057914 PMID:12604170 PMID:15371095 PMID:18653653 PMID:21356202 PMID:21461237 PMID:21607289 PMID:21777521 PMID:22154906 PMID:23099361 PMID:23999131 PMID:26582142 PMID:27339419 PMID:32345916 | CXCL2 | increases secretion | ISO | Cxcl2 (Rattus norvegicus) | 6480464 | CTD | Lipopolysaccharides results in increased secretion of CXCL2 protein | PMID:21362633 | CXCL2 | increases secretion | ISO | Cxcl2 (Mus musculus) | 6480464 | CTD | Lipopolysaccharides results in increased secretion of CXCL2 protein | PMID:15593098 PMID:18523137 PMID:22154906 PMID:32800949 | CXCL2 | multiple interactions | ISO | Cxcl2 (Rattus norvegicus) | 6480464 | CTD | [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CXCL2 mRNA; [Ranitidine co-treated with Lipopolysaccharides] results in increased expression of CXCL2 protein; alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CXCL2 mRNA]; Heparin inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]]; Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]; Lipopolysaccharides promotes the reaction [RELA protein binds to CXCL2 promoter]; oxymatrine inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to CXCL2 promoter]]; oxymatrine inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Pentoxifylline inhibits the reaction [[Ranitidine co-treated with Lipopolysaccharides] results in increased expression of CXCL2 protein]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein] | PMID:11545620 PMID:16401727 PMID:16415329 PMID:17698507 PMID:23568217 PMID:24333275 | CXCL2 | multiple interactions | ISO | Cxcl2 (Mus musculus) | 6480464 | CTD | [Lipopolysaccharides results in increased abundance of Prostaglandin D2] which results in increased expression of CXCL2 protein; [Ozone co-treated with Lipopolysaccharides] results in increased expression of CXCL2 mRNA; [pirinixic acid binds to and results in increased activity of PPARA protein] inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]; [Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of CXCL2 mRNA; bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CXCL2 protein]; Cathelicidins inhibits the reaction [[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of CXCL2 mRNA]; cordycepin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL2 protein]; Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; dopexamine inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Lipopolysaccharides results in increased expression of and results in increased secretion of CXCL2 protein; Oligopeptides inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Oligopeptides inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL2 protein]; P2RY6 gene affects the reaction [Uridine Diphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL2 protein]]; PARP1 protein affects the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]; PTGDR protein promotes the reaction [[Lipopolysaccharides results in increased abundance of Prostaglandin D2] which results in increased expression of CXCL2 protein]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]; Tetrachlorodibenzodioxin promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Uridine Diphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL2 protein] | PMID:11605937 PMID:11818323 PMID:12604170 PMID:18523137 PMID:18653653 PMID:21166666 PMID:21607289 PMID:21731756 PMID:22154906 PMID:23099361 PMID:23999131 PMID:26918785 PMID:38749002 | | ||||||||||||||||||||||
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