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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735621
Species: Homo sapiens
RGD Object: Gene
Symbol: CXCL2
Name: C-X-C motif chemokine ligand 2
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CXCL2increases expressionEXP 6480464CTDQuercetin results in increased expression of CXCL2 mRNAPMID:21632981
CXCL2decreases expressionISOCxcl2 (Rattus norvegicus)6480464CTDQuercetin results in decreased expression of CXCL2 mRNA; Quercetin results in decreased expression of CXCL2 proteinPMID:27525872
CXCL2multiple interactionsISOCxcl2 (Rattus norvegicus)6480464CTDQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of CXCL2 mRNA]PMID:26476374
CXCL2multiple interactionsISOCxcl2 (Mus musculus)6480464CTDQuercetin inhibits the reaction [CREBBP protein binds to CXCL2 promoter]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]; Quercetin inhibits the reaction [RELA protein modified form binds to CXCL2 promoter]; Quercetin inhibits the reaction [TNF protein promotes the reaction [CREBBP protein binds to CXCL2 promoter]]; Quercetin inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to CXCL2 promoter]]; Quercetin inhibits the reaction [TNF protein results in increased expression of CXCL2 mRNA]; Quercetin inhibits the reaction [TNF protein results in increased expression of CXCL2]PMID:17449583 PMID:21857970 PMID:23099361
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