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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735594
Species: Homo sapiens
RGD Object: Gene
Symbol: LDLR
Name: low density lipoprotein receptor
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LDLRincreases expressionEXP 6480464CTDAcetaminophen results in increased expression of LDLR mRNAPMID:21420995
LDLRmultiple interactionsEXP 6480464CTD[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of LDLR mRNA; Acetaminophen promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]; Acetaminophen promotes the reaction [Cholesterol, LDL binds to LDLR protein]PMID:10395027 PMID:33819548
LDLRdecreases expressionISOLdlr (Rattus norvegicus)6480464CTDAcetaminophen results in decreased expression of LDLR mRNAPMID:32479839 PMID:33387578
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